Topical immunotherapy for pseudomonas keratitis in rabbits: use of antilipopolysaccharide plasma.
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منابع مشابه
Topical immunotherapy for pseudomonas keratitis in rabbits: use of antilipopolysaccharide plasma.
Pseudomonas keratitis is currently treated with antibiotics with a variable success rate. Part of the morbidity caused by pseudomonas is due to the action of lipopolysaccharide (LPS) present on the surface membrane of the bacteria. Specific IgG present in equine anti-LPS hyper-immune plasma has been found to bind to the LPS from a range of Gram-negative bacteria, including pseudomonas, and by a...
متن کاملTopical fluconazole for experimental candida keratitis in rabbits.
Using a reproducible model of Candida albicans keratitis in rabbits we studied the effect of topical fluconazole, a new triazole. Candida albicans DSM 70010 (2.5 X 10(5) cells) was injected into the corneal stroma of both eyes of 21 rabbits. All eyes developed a corneal ulcer. Forty-eight hours after inoculation the animals were divided into three groups: (1) 14 eyes, received fluconazole (2 mg...
متن کامل[Use of topical voriconazole in Alternaria keratitis].
CLINICAL CASE A 38-year-old man with fungal Alternaria keratitis was referred from another hospital 25 days after post-traumatic penetrating keratoplastia surgery on his right eye. We commenced treatment with topical voriconazole and the condition resolved. DISCUSSION Fungal Alternaria keratitis is rare, and treatment is difficult because the clinical response does not correlate well with the...
متن کاملTopical piperacillin/tazobactam for recalcitrant pseudomonas aeruginosa keratitis.
PURPOSE To report the treatment of therapy-resistant Pseudomonas aeruginosa keratitis with topical piperacillin/tazobactam. METHODS Retrospective report of 3 cases. RESULTS Three patients with P. aeruginosa keratitis were unresponsive to various antimicrobials. Resolution of all 3 cases of keratitis occurred upon commencement of topical piperacillin/tazobactam. CONCLUSION Therapy-resistan...
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The role of mucin in the manifestation of Pseudomonas keratitis was studied. Pseudomonas was cultivated in solutions of mucin, in which it grew rapidly and then inoculated into rabbit cornea by needle pricks. When the organism was inoculated as a suspension in saline, infection infrequently occurred as small ring abscesses of short duration around a few sites of inoculation. When the organism w...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1984
ISSN: 0007-1161
DOI: 10.1136/bjo.68.11.828